The subject of potency disorders is a complex and multifaceted one, fraught with a dizzying array of both conflicting and converging factors. From a sedentary lifestyle to an addiction to cycling, there are countless reasons why one might experience erectile dysfunction (ED). But what are the true culprits behind this delicate issue?
Contrary to previous beliefs, research shows that up to 80% of ED cases are not caused by psychological factors, but rather by a host of physiological disorders. These include vascular, nervous, and hormonal imbalances, as well as a decrease in testosterone levels in the blood. Studies have shown that endothelial damage is a common thread in the pathogenesis of cardiovascular diseases, DM, and ED. All vascular risk factors have a detrimental effect on the synthesis of vasodilating agents, particularly nitric oxide, which plays a crucial role in the mechanism of erection. Disruption of its production and/or availability can lead to ED.
The list of risk factors for ED is extensive and varied. It includes cardiovascular diseases such as atherosclerosis, kidney failure, diseases of the endocrine system such as diabetes mellitus, hypo-, and hyperthyroidism, neurological diseases such as Alzheimer’s disease and multiple sclerosis, spinal injury such as spinal cord injury, Peyronie’s disease, drinking alcohol, smoking, taking certain drugs such as antihypertensive drugs, antidepressants, hormones, tranquilizers, and even depression.
So how is ED treated? Since 1998, phosphodiesterase type 5 inhibitors have been the first line of defense. These drugs include sildenafil (Viagra®, Olmax Strong, etc.), vardenafil (Levitra®), tadalafil (Cialis®), and udenafil (Zydena®). The specific drug prescribed by a doctor will depend on the patient’s condition, the causes of ED, and any underlying diseases.
Sildenafil, the ancestor of the iPDE-5 class, is available in both original and generic form. Generics such as Olmax Strong can be a more affordable and viable option for patients. It is available in three different dosages, which simplifies the selection process according to a doctor’s prescriptions. The recommended dosage is 1 hour before sexual activity, with a maximum recommended dose of 100 mg and maximum frequency of use being once per day.
Sildenafil works by selectively inhibiting specific PDE-5, preventing the breakdown of cGMP in the cavernous bodies. This enhances the relaxing effect of nitric oxide and improves blood flow, ultimately improving ED symptoms.