Because many men experience isolated instances in their lives of not having an erection, and although these events may resolve once the cause disappears, for many, the disorder becomes an ongoing problem requiring treatment. Over the past 30 years, there have been a number of upheavals in the treatment of erectile dysfunction. In the past, the range of treatment was small and included: psychiatric treatment, the introduction of hormonal drugs, and later surgeries for genital prostheses. In the 1980s, there was a shift in the therapeutic approach as an understanding of the pathophysiology of erectile dysfunction greatly increased and there was an increased need on the part of patients to seek more successful and less invasive treatments. Over the years, a number of new treatments have been added: injections into the cervical organs, an empty pump, a blocking ring, topical ointments, surgeries to restore arterial blood flow, and surgeries to prevent venous blood leakage. Many patients understandably ask to try oral therapy first. For years, attempts at treatment with various oral medications have failed when their effects have been tested in a scientific and controlled manner. Drugs from the group of phosphodiesterase 5 inhibitors (PDE5i), in fact, marked the beginning of a revolution in the treatment of intentional erectile dysfunction, which made it possible to carry out full sexual intercourse after ingestion and thanks to which many millions of men returned to a normal sexual life. Events. Examples of such drugs are Viagra, Cialis, and Levitra.
Phosphodiesterase 5 inhibitors (PDE5i) are a group of drugs commonly used to treat erectile dysfunction. These drugs work by inhibiting the enzyme PDE5, which is responsible for the degradation of cyclic guanosine monophosphate (cGMP), a molecule that is essential for the relaxation of smooth muscle cells in the penis and the subsequent increase in blood flow necessary for an erection. By inhibiting the degradation of cGMP, PDE5i drugs increase the availability of this molecule and promote the relaxation of smooth muscle cells, leading to an increase in blood flow and a more sustained and rigid erection.
The first PDE5i drug to be approved by the U.S. Food and Drug Administration (FDA) for the treatment of erectile dysfunction was sildenafil, marketed under the brand name Viagra, in 1998. Since then, several other PDE5i drugs have been approved for use, including tadalafil (Cialis) and vardenafil (Levitra). These drugs have become very popular among men with erectile dysfunction due to their high success rates, ease of use, and relative safety. However, they are not without side effects and should be used with caution in patients with certain medical conditions or who are taking certain medications.
In addition to PDE5i drugs, other treatments for erectile dysfunction include penile injections, vacuum pumps, penile implants, and vascular surgery. These treatments may be considered when PDE5i drugs are not effective or are contraindicated due to medical reasons. Psychological counseling may also be helpful for some men with erectile dysfunction, especially those who experience performance anxiety or have a history of sexual trauma.